KEGG pathway name : HIF-1 signaling pathway
gene symbol INSR species H.sapiens chromosome 19
protein Name insulin receptor preproprotein num of AS variants 3
AS position Mid
C-ter		 AS type INDEL
SUB		 3D data on AS Available
link View this protein in the KEGG pathway map (*)

(* In the map, this protein is shown in yellow along with other proteins subjected to AS shown in pink.)


other proteins subjected to AS in HIF-1 signaling pathway
1 gene symbol HK1 species H.sapiens chromosome 10
protein Name hexokinase-1 num of AS variants 7
AS position N-ter
Mid		 AS type INDEL
SUB		 3D data on AS Available
link View this protein in the KEGG pathway map

2 gene symbol HK2 species H.sapiens chromosome 2
protein Name hexokinase-2 num of AS variants 2
AS position N-ter AS type INDEL 3D data on AS Available
link View this protein in the KEGG pathway map

3 gene symbol PDHA1 species H.sapiens chromosome X
protein Name pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial precursor num of AS variants 8
AS position N-ter
Mid
C-ter		 AS type INDEL
SUB		 3D data on AS Available
link View this protein in the KEGG pathway map

4 gene symbol TEK species H.sapiens chromosome 9
protein Name angiopoietin-1 receptor precursor num of AS variants 4
AS position Mid
C-ter		 AS type INDEL
SUB		 3D data on AS Available
link View this protein in the KEGG pathway map

5 gene symbol VHL species H.sapiens chromosome 3
protein Name von Hippel-Lindau disease tumor suppressor num of AS variants 2
AS position Mid AS type INDEL 3D data on AS Available
link View this protein in the KEGG pathway map

6 gene symbol IL6R species H.sapiens chromosome 1
protein Name interleukin-6 receptor subunit alpha precursor num of AS variants 4
AS position C-ter AS type SUB 3D data on AS Available
link View this protein in the KEGG pathway map

7 gene symbol IL6 species H.sapiens chromosome 7
protein Name interleukin-6 precursor num of AS variants 5
AS position N-ter
Mid
C-ter		 AS type INDEL
SUB		 3D data on AS Available
link View this protein in the KEGG pathway map

8 gene symbol NOS3 species H.sapiens chromosome 7
protein Name nitric oxide synthase, endothelial num of AS variants 5
AS position N-ter
C-ter		 AS type INDEL
SUB		 3D data on AS Available
link View this protein in the KEGG pathway map

9 gene symbol NOS2 species H.sapiens chromosome 17
protein Name nitric oxide synthase, inducible num of AS variants 2
AS position Mid AS type INDEL 3D data on AS Available
link View this protein in the KEGG pathway map

10 gene symbol BCL2 species H.sapiens chromosome 18
protein Name apoptosis regulator Bcl-2 alpha isoform num of AS variants 2
AS position C-ter AS type SUB 3D data on AS Available
link View this protein in the KEGG pathway map

11 gene symbol IGF1R species H.sapiens chromosome 15
protein Name insulin-like growth factor 1 receptor precursor num of AS variants 2
AS position Mid AS type INDEL 3D data on AS -
link View this protein in the KEGG pathway map

12 gene symbol PDHB species H.sapiens chromosome 3
protein Name pyruvate dehydrogenase E1 component subunit beta, mitochondrial precursor num of AS variants 5
AS position Mid
C-ter		 AS type INDEL
SUB		 3D data on AS Available
link View this protein in the KEGG pathway map

13 gene symbol RPS6 species H.sapiens chromosome 9
protein Name 40S ribosomal protein S6 num of AS variants 3
AS position N-ter
C-ter		 AS type INDEL
SUB		 3D data on AS Available
link View this protein in the KEGG pathway map

14 gene symbol VEGFA species H.sapiens chromosome 6
protein Name vascular endothelial growth factor A num of AS variants 21
AS position Mid
C-ter		 AS type INDEL
SUB		 3D data on AS Available
link View this protein in the KEGG pathway map

15 gene symbol TF species H.sapiens chromosome 3
protein Name serotransferrin precursor num of AS variants 4
AS position C-ter AS type SUB 3D data on AS Available
link View this protein in the KEGG pathway map

16 gene symbol IGF1 species H.sapiens chromosome 12
protein Name insulin-like growth factor I preproprotein num of AS variants 5
AS position N-ter
C-ter		 AS type SUB 3D data on AS -
link View this protein in the KEGG pathway map

17 gene symbol ANGPT1 species H.sapiens chromosome 8
protein Name angiopoietin-1 precursor num of AS variants 4
AS position N-ter
Mid		 AS type INDEL 3D data on AS Available
link View this protein in the KEGG pathway map

18 gene symbol ANGPT2 species H.sapiens chromosome 8
protein Name angiopoietin-2 precursor num of AS variants 4
AS position Mid
C-ter		 AS type INDEL
SUB		 3D data on AS Available
link View this protein in the KEGG pathway map

19 gene symbol NFKB1 species H.sapiens chromosome 4
protein Name nuclear factor NF-kappa-B p105 subunit proprotein num of AS variants 4
AS position N-ter
Mid		 AS type INDEL
SUB		 3D data on AS Available
link View this protein in the KEGG pathway map

20 gene symbol LDHA species H.sapiens chromosome 11
protein Name L-lactate dehydrogenase A chain num of AS variants 11
AS position N-ter
Mid
C-ter		 AS type INDEL
SUB		 3D data on AS Available
link View this protein in the KEGG pathway map

21 gene symbol CUL2 species H.sapiens chromosome 10
protein Name cullin-2 num of AS variants 7
AS position N-ter
Mid
C-ter		 AS type INDEL
SUB		 3D data on AS Available
link View this protein in the KEGG pathway map

22 gene symbol CAMK2B species H.sapiens chromosome 7
protein Name calcium/calmodulin-dependent protein kinase type II subunit beta num of AS variants 12
AS position Mid
C-ter		 AS type INDEL
SUB		 3D data on AS Available
link View this protein in the KEGG pathway map

23 gene symbol CDKN1A species H.sapiens chromosome 6
protein Name cyclin-dependent kinase inhibitor 1 num of AS variants 2
AS position N-ter AS type INDEL 3D data on AS -
link View this protein in the KEGG pathway map

24 gene symbol CAMK2D species H.sapiens chromosome 4
protein Name calcium/calmodulin-dependent protein kinase type II subunit delta num of AS variants 31
AS position N-ter
Mid
C-ter		 AS type INDEL
SUB		 3D data on AS Available
link View this protein in the KEGG pathway map

25 gene symbol ENO4 species H.sapiens chromosome 10
protein Name enolase 4 num of AS variants 4
AS position N-ter
Mid
C-ter		 AS type INDEL
SUB		 3D data on AS Available
link View this protein in the KEGG pathway map

26 gene symbol ALDOA species H.sapiens chromosome 16
protein Name fructose-bisphosphate aldolase A num of AS variants 6
AS position N-ter
Mid
C-ter		 AS type INDEL
SUB		 3D data on AS Available
link View this protein in the KEGG pathway map

27 gene symbol GAPDH species H.sapiens chromosome 12
protein Name glyceraldehyde-3-phosphate dehydrogenase num of AS variants 4
AS position N-ter AS type INDEL
SUB		 3D data on AS Available
link View this protein in the KEGG pathway map

28 gene symbol ENO1 species H.sapiens chromosome 1
protein Name alpha-enolase num of AS variants 3
AS position N-ter AS type INDEL 3D data on AS Available
link View this protein in the KEGG pathway map

29 gene symbol HIF1A species H.sapiens chromosome 14
protein Name hypoxia-inducible factor 1-alpha num of AS variants 5
AS position N-ter
Mid
C-ter		 AS type INDEL
SUB		 3D data on AS Available
link View this protein in the KEGG pathway map

30 gene symbol AKT2 species H.sapiens chromosome 19
protein Name RAC-beta serine/threonine-protein kinase num of AS variants 11
AS position N-ter
Mid
C-ter		 AS type INDEL
SUB		 3D data on AS Available
link View this protein in the KEGG pathway map

31 gene symbol ARNT species H.sapiens chromosome 1
protein Name aryl hydrocarbon receptor nuclear translocator num of AS variants 7
AS position N-ter
Mid
C-ter		 AS type INDEL
SUB		 3D data on AS Available
link View this protein in the KEGG pathway map

32 gene symbol EDN1 species H.sapiens chromosome 6
protein Name endothelin-1 preproprotein num of AS variants 2
AS position Mid AS type INDEL 3D data on AS -
link View this protein in the KEGG pathway map

33 gene symbol EGF species H.sapiens chromosome 4
protein Name pro-epidermal growth factor preproprotein num of AS variants 3
AS position Mid AS type INDEL 3D data on AS Available
link View this protein in the KEGG pathway map

34 gene symbol EIF4E species H.sapiens chromosome 4
protein Name eukaryotic translation initiation factor 4E num of AS variants 5
AS position N-ter
Mid
C-ter		 AS type INDEL
SUB		 3D data on AS Available
link View this protein in the KEGG pathway map

35 gene symbol ENO2 species H.sapiens chromosome 12
protein Name gamma-enolase num of AS variants 4
AS position Mid
C-ter		 AS type INDEL
SUB		 3D data on AS Available
link View this protein in the KEGG pathway map

36 gene symbol ENO3 species H.sapiens chromosome 17
protein Name beta-enolase num of AS variants 5
AS position Mid
C-ter		 AS type INDEL
SUB		 3D data on AS Available
link View this protein in the KEGG pathway map

37 gene symbol FLT1 species H.sapiens chromosome 13
protein Name vascular endothelial growth factor receptor 1 precursor num of AS variants 8
AS position N-ter
C-ter		 AS type INDEL
SUB		 3D data on AS Available
link View this protein in the KEGG pathway map

38 gene symbol HK3 species H.sapiens chromosome 5
protein Name hexokinase-3 num of AS variants 3
AS position Mid
C-ter		 AS type INDEL
SUB		 3D data on AS Available
link View this protein in the KEGG pathway map

39 gene symbol LTBR species H.sapiens chromosome 12
protein Name tumor necrosis factor receptor superfamily member 3 precursor num of AS variants 5
AS position N-ter
Mid
C-ter		 AS type INDEL
SUB		 3D data on AS Available
link View this protein in the KEGG pathway map

40 gene symbol PDK1 species H.sapiens chromosome 2
protein Name [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 1, mitochondrial precursor num of AS variants 5
AS position N-ter
Mid
C-ter		 AS type INDEL
SUB		 3D data on AS Available
link View this protein in the KEGG pathway map

41 gene symbol PFKL species H.sapiens chromosome 21
protein Name ATP-dependent 6-phosphofructokinase, liver type num of AS variants 3
AS position N-ter
C-ter		 AS type SUB 3D data on AS Available
link View this protein in the KEGG pathway map

42 gene symbol PLCG2 species H.sapiens chromosome 16
protein Name 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 num of AS variants 2
AS position C-ter AS type SUB 3D data on AS -
link View this protein in the KEGG pathway map

43 gene symbol PRKCA species H.sapiens chromosome 17
protein Name protein kinase C alpha type num of AS variants 2
AS position C-ter AS type SUB 3D data on AS Available
link View this protein in the KEGG pathway map

44 gene symbol PRKCG species H.sapiens chromosome 19
protein Name protein kinase C gamma type num of AS variants 2
AS position C-ter AS type SUB 3D data on AS -
link View this protein in the KEGG pathway map

45 gene symbol MAPK1 species H.sapiens chromosome 22
protein Name mitogen-activated protein kinase 1 num of AS variants 2
AS position Mid AS type INDEL 3D data on AS Available
link View this protein in the KEGG pathway map

46 gene symbol MAPK3 species H.sapiens chromosome 16
protein Name mitogen-activated protein kinase 3 num of AS variants 9
AS position N-ter
Mid
C-ter		 AS type INDEL
SUB		 3D data on AS Available
link View this protein in the KEGG pathway map

47 gene symbol MAP2K1 species H.sapiens chromosome 15
protein Name dual specificity mitogen-activated protein kinase kinase 1 num of AS variants 2
AS position N-ter AS type SUB 3D data on AS Available
link View this protein in the KEGG pathway map

48 gene symbol RPS6KB1 species H.sapiens chromosome 17
protein Name ribosomal protein S6 kinase beta-1 num of AS variants 8
AS position N-ter
Mid
C-ter		 AS type INDEL
SUB		 3D data on AS Available
link View this protein in the KEGG pathway map

49 gene symbol TFRC species H.sapiens chromosome 3
protein Name transferrin receptor protein 1 num of AS variants 5
AS position N-ter
C-ter		 AS type INDEL
SUB		 3D data on AS Available
link View this protein in the KEGG pathway map

50 gene symbol TIMP1 species H.sapiens chromosome X
protein Name metalloproteinase inhibitor 1 precursor num of AS variants 3
AS position N-ter
C-ter		 AS type INDEL
SUB		 3D data on AS Available
link View this protein in the KEGG pathway map

51 gene symbol PIK3R3 species H.sapiens chromosome 1
protein Name phosphatidylinositol 3-kinase regulatory subunit gamma num of AS variants 4
AS position N-ter
Mid		 AS type INDEL
SUB		 3D data on AS Available
link View this protein in the KEGG pathway map

52 gene symbol MKNK1 species H.sapiens chromosome 1
protein Name MAP kinase-interacting serine/threonine-protein kinase 1 num of AS variants 11
AS position N-ter
Mid
C-ter		 AS type INDEL
SUB		 3D data on AS Available
link View this protein in the KEGG pathway map

53 gene symbol RPS6KB2 species H.sapiens chromosome 11
protein Name ribosomal protein S6 kinase beta-2 num of AS variants 6
AS position N-ter
Mid
C-ter		 AS type INDEL
SUB		 3D data on AS Available
link View this protein in the KEGG pathway map

54 gene symbol CDKN1B species H.sapiens chromosome 12
protein Name cyclin-dependent kinase inhibitor 1B num of AS variants 3
AS position Mid
C-ter		 AS type INDEL
SUB		 3D data on AS -
link View this protein in the KEGG pathway map

55 gene symbol CREBBP species H.sapiens chromosome 16
protein Name CREB-binding protein num of AS variants 2
AS position Mid AS type INDEL 3D data on AS Available
link View this protein in the KEGG pathway map

56 gene symbol ERBB2 species H.sapiens chromosome 17
protein Name receptor tyrosine-protein kinase erbB-2 precursor num of AS variants 8
AS position N-ter
Mid
C-ter		 AS type INDEL
SUB		 3D data on AS Available
link View this protein in the KEGG pathway map

57 gene symbol PFKFB3 species H.sapiens chromosome 10
protein Name 6-phosphofructo-2-kinase/fructose-2, 6-bisphosphatase 3 num of AS variants 13
AS position N-ter
Mid
C-ter		 AS type INDEL
SUB		 3D data on AS Available
link View this protein in the KEGG pathway map

58 gene symbol EIF4E2 species H.sapiens chromosome 2
protein Name eukaryotic translation initiation factor 4E type 2 num of AS variants 7
AS position Mid
C-ter		 AS type INDEL
SUB		 3D data on AS Available
link View this protein in the KEGG pathway map

59 gene symbol MTOR species H.sapiens chromosome 1
protein Name serine/threonine-protein kinase mTOR num of AS variants 3
AS position N-ter AS type INDEL 3D data on AS Available
link View this protein in the KEGG pathway map

60 gene symbol PIK3CD species H.sapiens chromosome 1
protein Name phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform num of AS variants 4
AS position Mid AS type INDEL
SUB		 3D data on AS Available
link View this protein in the KEGG pathway map

61 gene symbol PIK3R2 species H.sapiens chromosome 19
protein Name phosphatidylinositol 3-kinase regulatory subunit beta num of AS variants 2
AS position C-ter AS type SUB 3D data on AS Available
link View this protein in the KEGG pathway map

62 gene symbol AKT1 species H.sapiens chromosome 14
protein Name RAC-alpha serine/threonine-protein kinase num of AS variants 3
AS position N-ter
C-ter		 AS type INDEL
SUB		 3D data on AS Available
link View this protein in the KEGG pathway map

63 gene symbol EGFR species H.sapiens chromosome 7
protein Name epidermal growth factor receptor precursor num of AS variants 8
AS position N-ter
Mid
C-ter		 AS type INDEL
SUB		 3D data on AS Available
link View this protein in the KEGG pathway map

64 gene symbol AKT3 species H.sapiens chromosome 1
protein Name RAC-gamma serine/threonine-protein kinase num of AS variants 3
AS position C-ter AS type SUB 3D data on AS Available
link View this protein in the KEGG pathway map

65 gene symbol IFNGR2 species H.sapiens chromosome 21
protein Name interferon gamma receptor 2 precursor num of AS variants 5
AS position N-ter
Mid
C-ter		 AS type INDEL
SUB		 3D data on AS Available
link View this protein in the KEGG pathway map

66 gene symbol NPPA species H.sapiens chromosome 1
protein Name natriuretic peptides A preproprotein num of AS variants 3
AS position N-ter
C-ter		 AS type INDEL
SUB		 3D data on AS -
link View this protein in the KEGG pathway map

67 gene symbol PIK3CB species H.sapiens chromosome 3
protein Name phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta 1 num of AS variants 6
AS position N-ter
Mid
C-ter		 AS type INDEL
SUB		 3D data on AS Available
link View this protein in the KEGG pathway map

68 gene symbol SLC2A1 species H.sapiens chromosome 1
protein Name solute carrier family 2, facilitated glucose transporter member 1 num of AS variants 4
AS position Mid
C-ter		 AS type INDEL
SUB		 3D data on AS Available
link View this protein in the KEGG pathway map

69 gene symbol TCEB2 species H.sapiens chromosome 16
protein Name transcription elongation factor B polypeptide 2 num of AS variants 5
AS position N-ter
Mid
C-ter		 AS type INDEL
SUB		 3D data on AS Available
link View this protein in the KEGG pathway map

70 gene symbol ANGPT4 species H.sapiens chromosome 20
protein Name angiopoietin-4 precursor num of AS variants 2
AS position C-ter AS type SUB 3D data on AS Available
link View this protein in the KEGG pathway map

71 gene symbol RELA species H.sapiens chromosome 11
protein Name transcription factor p65 num of AS variants 13
AS position N-ter
Mid
C-ter		 AS type INDEL
SUB		 3D data on AS Available
link View this protein in the KEGG pathway map

72 gene symbol EGLN3 species H.sapiens chromosome 14
protein Name egl nine homolog 3 num of AS variants 3
AS position N-ter
Mid		 AS type INDEL
SUB		 3D data on AS Available
link View this protein in the KEGG pathway map

73 gene symbol MAP2K2 species H.sapiens chromosome 19
protein Name dual specificity mitogen-activated protein kinase kinase 2 num of AS variants 2
AS position N-ter AS type INDEL 3D data on AS Available
link View this protein in the KEGG pathway map

74 gene symbol EGLN2 species H.sapiens chromosome 19
protein Name egl nine homolog 2 num of AS variants 7
AS position N-ter
Mid		 AS type INDEL 3D data on AS Available
link View this protein in the KEGG pathway map

75 gene symbol TLR4 species H.sapiens chromosome 9
protein Name toll-like receptor 4 precursor num of AS variants 3
AS position N-ter AS type INDEL 3D data on AS Available
link View this protein in the KEGG pathway map

76 gene symbol STAT3 species H.sapiens chromosome 17
protein Name signal transducer and activator of transcription 3 num of AS variants 5
AS position N-ter
Mid
C-ter		 AS type INDEL
SUB		 3D data on AS Available
link View this protein in the KEGG pathway map

77 gene symbol CAMK2A species H.sapiens chromosome 5
protein Name calcium/calmodulin-dependent protein kinase type II subunit alpha num of AS variants 2
AS position Mid AS type INDEL 3D data on AS Available
link View this protein in the KEGG pathway map

78 gene symbol CAMK2G species H.sapiens chromosome 10
protein Name calcium/calmodulin-dependent protein kinase type II subunit gamma num of AS variants 11
AS position Mid
C-ter		 AS type INDEL
SUB		 3D data on AS Available
link View this protein in the KEGG pathway map

79 gene symbol PIK3R1 species H.sapiens chromosome 5
protein Name phosphatidylinositol 3-kinase regulatory subunit alpha num of AS variants 6
AS position N-ter AS type INDEL
SUB		 3D data on AS Available
link View this protein in the KEGG pathway map

80 gene symbol PLCG1 species H.sapiens chromosome 20
protein Name 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 num of AS variants 5
AS position Mid
C-ter		 AS type INDEL
SUB		 3D data on AS Available
link View this protein in the KEGG pathway map

81 gene symbol MKNK2 species H.sapiens chromosome 19
protein Name MAP kinase-interacting serine/threonine-protein kinase 2 num of AS variants 6
AS position N-ter
C-ter		 AS type INDEL
SUB		 3D data on AS Available
link View this protein in the KEGG pathway map

82 gene symbol PRKCB species H.sapiens chromosome 16
protein Name protein kinase C beta type num of AS variants 3
AS position C-ter AS type SUB 3D data on AS Available
link View this protein in the KEGG pathway map